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KMID : 0855520130260020071
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Korean Journal of Physical Anthropology
2013 Volume.26 No. 2 p.71 ~ p.79
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Role of IL-10 in the Trimellitic Anhydride-induced Contact Dermatitis
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Kim Yun-Kyu
Chai Ok-Hee
Song Chang-Ho
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Abstract
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Trimellitic anhydride (TMA) is widely used industrially to make epoxy and alkyd resins, plasticizers and surfactants.
The purpose of this study was to investigate whether contact dermatitis is induced by repeated TMA challenge and the role of interleukin (IL)-10 in the TMA-induced contact dermatitis.
The repetition of the challenge enlarged the extent of an early and a late phase of contact dermatitis in IL-10+/+ and IL-10-/- mice. In the late phase of TMA-induced contact dermatitis, the peak of ear swelling responses by single challenge showed at 12 h after challenge, but the peak was observed at 8 h after repeated challenge. In the IL-10-/- mice, the repetition of the TMA challenges enlarged the extent of the contact dermatitis, but less than those in IL-10+/+ mice.
These results indicate that mice sensitized by TMA could possibly offer a useful model to study the mechanism of contact dermatitis, and IL-10 may act as potential modulators in the TMA-induced contact dermatitis. IL-10 may provide therapeutic tools for the treatment of TMA-induced contact dermatitis.
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KEYWORD
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IL-10, Contact dermatitis, Ear swelling, trimellitic anhydride
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